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Multistage analysis method for detection of effective herb prescription from clinical data

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《医学前沿(英文)》 2018年 第12卷 第2期   页码 206-217 doi: 10.1007/s11684-017-0525-8

摘要:

Determining effective traditional Chinese medicine (TCM) treatments for specific disease conditions or particular patient groups is a difficult issue that necessitates investigation because of the complicated personalized manifestations in real-world patients and the individualized combination therapies prescribed in clinical settings. In this study, a multistage analysis method that integrates propensity case matching, complex network analysis, and herb set enrichment analysis was proposed to identify effective herb prescriptions for particular diseases (e.g., insomnia). First, propensity case matching was applied to match clinical cases. Then, core network extraction and herb set enrichment were combined to detect core effective herb prescriptions. Effectiveness-based mutual information was used to detect strong herb–symptom relationships. This method was applied on a TCM clinical data set with 955 patients collected from well-designed observational studies. Results revealed that groups of herb prescriptions with higher effectiveness rates (76.9% vs. 42.8% for matched samples; 94.2% vs. 84.9% for all samples) compared with the original prescriptions were found. Particular patient groups with symptom manifestations were also identified to help investigate the indications of the effective herb prescriptions.

关键词: effective prescription detection     herb set enrichment analysis     core network extraction     insomnia     personalized treatment    

遥感和精准农业技术在作物病害检测与管理中的应用实例 Review

杨成海

《工程(英文)》 2020年 第6卷 第5期   页码 528-532 doi: 10.1016/j.eng.2019.10.015

摘要:

长期以来,遥感技术一直被应用于作物病害的检测和地图绘制工作。在作物生长季节获得的机载和卫星图像不仅可以用于某些病害的早期发现和季节内管理,还可用于未来季节中复发性病害的管控。尽管传统的地毯式杀虫剂施用更适于对付能够迅速在田间传播的病害,然而,在作物病害稳定的情况下,精准农业中的变量控制技术(VRT)亦可以有针对性地对受感染地区的作物有效施用杀菌剂。本文简述了已用于作物病害检测和管理的遥感技术和精准农业技术。具体来说,本文详细阐明了利用机载技术、卫星图像和VRT在棉田中检测棉花根腐病(一种破坏性的土壤传播性真菌病)和绘制分布地图的原理,介绍了从图像中提取处方图以施用定点杀菌剂并有效控制作物病害的方法。本文介绍的案例和方法力图为研究人员、推广人员、种植者、作物顾问、农场设备和化学品经销商提供有关遥感检测和有效管理某些作物病害的实用指南。

关键词: 作物病害     机载成像     高分辨率卫星成像     棉花根腐病     处方图     变量控制技术    

通用、有效且轻量的PowerShell解混淆和语义敏感的攻击检测方法 Research Articles

熊春霖1,李振源1,陈焰2,朱添田3,王箭1,杨海4,阮伟5

《信息与电子工程前沿(英文)》 2022年 第23卷 第3期   页码 361-381 doi: 10.1631/FITEE.2000436

摘要: 近年来,PowerShell攻击越来越多见诸报道。然而,由于PowerShell语言的动态特性,且可在不同级别构造脚本片段,即使基于最先进的静态脚本分析的PowerShell攻击检测方法,其本质上也容易受到混淆的影响。本文为PowerShell脚本设计了一种通用、有效且轻量的去混淆方法。首先,为精准识别模糊脚本片段,根据混淆方法对PowerShell抽象语法树的影响,提出一种全新混淆片段检测方法,在此基础上提出一种基于仿真的恢复技术。此外,设计了一个语义敏感的PowerShell攻击检测系统,该系统利用经典的面向目标的关联挖掘算法,新识别31个用于恶意脚本检测的语义特征。在2342个良性样本和4141个恶意样本上的实验结果表明,所提去混淆方法平均耗时不到0.5秒,且将模糊脚本和原始脚本的相似度从0.5%提至93.2%。采用该去混淆方法,Windows Defender和VirusTotal的攻击检测率分别从0.33%和2.65%提至78.9%和94.0%。实验还表明,我们的检测系统优于现有两种工具(平均真正例率为96.7%,假正例率为0%)。

关键词: PowerShell;抽象语法树;混淆和解混淆;恶意脚本检测    

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

null

《医学前沿(英文)》 2012年 第6卷 第3期   页码 288-295 doi: 10.1007/s11684-012-0208-4

摘要:

Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants were allocated a different tramadol dose. Pain intensity was measured by face, legs, activity, cry, consolability (FLACC) measurement at 3-hour intervals. Tramadol was considered ineffective if the FLACC score was higher than 4 in 10 at anytime. In phase 1, seven dose levels were used within the range 0.1–0.4 mg?kg-1·h-1. Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?kg-1·h-1 in phase 2. Phase 2 was insufficient to identify the MED. In phase 3, local anesthetic wound infiltration was introduced, and the tramadol dose levels tested were the same as in phase 1. The successful analgesia probability of tramadol 0.4 mg?kg-1?h-1 was 82.1% (95% CI, 0.742–0.925) in phase 1. In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?h-1. Phase 1 and phase 2 were insufficient to identify the MED. In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?h-1was 96.7% (95% CI, 0.853–0.997).We have demonstrated that tramadol provides insufficient analgesia for surgeries considered to cause moderate-to-severe postoperative pain in infants if used as the sole analgesic, and that local anesthetic wound infiltration enhances the efficacy of tramadol.

关键词: tramadol     minimum effective dose     postoperative analgesia     infants     continual reassessment method    

Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

《医学前沿(英文)》 2007年 第1卷 第1期   页码 11-19 doi: 10.1007/s11684-007-0003-9

摘要: A remarkable advance in tumor immunology during the last decade is the elucidation of the antigenic basis of tumor recognition and destruction. A variety of tumor antigens have been identified using several strategies including conventional experiments and newly developed bioinformatics. Among these antigens, cancer/testis antigen (CT antigen) is considered to be the most promising target for immunotherapy by vaccination. Successful immunotherapy of tumors requires understanding of the natural relationship between the immune system and tumor in the status of differentiation, invasion and maturation. Continued progress in development of effective cancer vaccines depends on the identification of appropriate target antigens, the establishment of optimal immunization strategies without harmful autoimmune responses and the ability of manipulating tumor microenvironment to circumvent immune suppression and to augment the anti-tumor immune response.

关键词: development     conventional     identification     elucidation     Successful immunotherapy    

Z-scheme CdS/WO on a carbon cloth enabling effective hydrogen evolution

《能源前沿(英文)》 2021年 第15卷 第3期   页码 678-686 doi: 10.1007/s11708-021-0768-6

摘要: Photocatalytic water splitting for hydrogen (H2) generation is a potential strategy to solve the problem of energy crisis and environmental deterioration. However, powder-like photocatalysts are difficult to recycle, and the agglomeration of particles would affect the photocatalytic activity. Herein, a direct Z-scheme CdS/WO3 composite photocatalyst was fabricated based on carbon cloth through a two-step process. With the support of carbon cloth, photocatalysts tend to grow uniformly for further applications. The experimental results showed that the H2 yield of adding one piece of CdS/WO3 composite material was 17.28 μmol/h, which was 5.5 times as compared to that of pure CdS-loaded carbon cloth material. A cycle experiment was conducted to verify the stability of the as-prepared material and the result demonstrated that the H2 generation performance of CdS/WO3 decreased slightly after 3 cycles. This work provides new ideas for the development of recyclable photocatalysts and has a positive significance for practical applications.

关键词: photocatalysis     CdS/WO3     carbon cloth     Z-scheme     hydrogen evolution    

Determination of effective stress parameter of unsaturated soils: A Gaussian process regression approach

Pijush Samui, Jagan J

《结构与土木工程前沿(英文)》 2013年 第7卷 第2期   页码 133-136 doi: 10.1007/s11709-013-0202-1

摘要: This article examines the capability of Gaussian process regression (GPR) for prediction of effective stress parameter ( ) of unsaturated soil. GPR method proceeds by parameterising a covariance function, and then infers the parameters given the data set. Input variables of GPR are net confining pressure ( ), saturated volumetric water content ( ), residual water content ( ), bubbling pressure ( ), suction ( ) and fitting parameter ( ). A comparative study has been carried out between the developed GPR and Artificial Neural Network (ANN) models. A sensitivity analysis has been done to determine the effect of each input parameter on . The developed GPR gives the variance of predicted . The results show that the developed GPR is reliable model for prediction of of unsaturated soil.

关键词: unsaturated soil     effective stress parameter     Gaussian process regression (GPR)     artificial neural network (ANN)     variance    

OPPORTUNITIES AND APPROACHES FOR MANIPULATING SOIL-PLANT MICROBIOMES FOR EFFECTIVE CROP NITROGEN USE

《农业科学与工程前沿(英文)》 2022年 第9卷 第3期   页码 333-343 doi: 10.15302/J-FASE-2022450

摘要:

● Matching nitrification inhibitors with soil properties and nitrifiers is vital to achieve a higher NUE.

关键词: nitrogen     microbiome     NUE     rhizosphere     phyllosphere     soil food web    

Facile fabrication of dolomite-doped biochar/bentonite for effective removal of phosphate from complex

《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1671-7

摘要:

● Dolomite-doped biochar/bentonite was synthesized for phosphate removal.

关键词: Biochar-bentonite composite     Dolomite doping     Phosphate adsorption     Polymeric matrix membrane     Adsorption-filtration dual functions     Low-concentration phosphate    

Usability perceptions and beliefs about smart thermostats by chi-square test, signal detection theory, and fuzzy detection theory in regions of Mexico

Pedro PONCE, Therese PEFFER, Arturo MOLINA

《能源前沿(英文)》 2019年 第13卷 第3期   页码 522-538 doi: 10.1007/s11708-018-0562-2

摘要: It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes; thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.

关键词: thermostats     perceptions     beliefs     signal detection theory (SDT)     fuzzy signal detection theory (FSDT)     chi-square (CS) test    

Advances in airborne microorganisms detection using biosensors: A critical review

《环境科学与工程前沿(英文)》 2021年 第15卷 第3期 doi: 10.1007/s11783-021-1420-8

摘要:

Humanity has been facing the threat of a variety of infectious diseases. Airborne microorganisms can cause airborne infectious diseases, which spread rapidly and extensively, causing huge losses to human society on a global scale. In recent years, the detection technology for airborne microorganisms has developed rapidly; it can be roughly divided into biochemical, immune, and molecular technologies.

关键词: Biosensor     Airborne microorganisms     Microbiological detection technology    

Recent advances in SERS detection of perchlorate

Jumin Hao, Xiaoguang Meng

《化学科学与工程前沿(英文)》 2017年 第11卷 第3期   页码 448-464 doi: 10.1007/s11705-017-1611-9

摘要: Perchlorate has recently emerged as a widespread environmental contaminant of healthy concern. Development of novel detection methods for perchlorate with the potential for field use has been an urgent need. The investigation has shown that surface-enhanced Raman scattering (SERS) technique has great potential to become a practical analysis tool for the rapid screening and routine monitoring of perchlorate in the field, particularly when coupled with portable/handheld Raman spectrometers. In this review article, we summarize progress made in SERS analysis of perchlorate in water and other media with an emphasis on the development of SERS substrates for perchlorate detection. The potential of this technique for fast screening and field testing of perchlorate-contaminated environmental samples is discussed. The challenges and possible solutions are also addressed, aiming to provide a better understanding on the development directions in the research field.

关键词: perchlorate     SERS     detection     substrate     modification     nanostructure    

UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1379-x

摘要:

• UV-LED with shorter wavelength was beneficial for photocatalytic degradation.

关键词: Degradation     Photocatalytic     LED     CMIT     P25    

A fast antibiotic detection method for simplified pretreatment through spectra-based machine learning

《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1472-9

摘要:

• A spectral machine learning approach is proposed for predicting mixed antibiotic.

关键词: Antibiotic contamination     Spectral detection     Machine learning    

and properties of PES/SPSf loose nanofiltration membranes using SPES as a hydrophilic polymer for the effective

《化学科学与工程前沿(英文)》 2023年 第17卷 第10期   页码 1555-1567 doi: 10.1007/s11705-023-2338-4

摘要: Herein, polyethersulfone (PES) and sulfonated polysulfone (SPSf) blend membranes were prepared with addition of sulfonated polyethersulfone (SPES) as a hydrophilic polymer and adipic acid as a porogen via non-solvent induced phase separation method for effective fractionation of dyes based on the influence of steric hindrance and charge effect. Raman spectroscopy and molecular dynamic simulation modeling confirmed that hydrogen bonds between PES, SPSf, SPES, and adipic acid were crucial to membrane formation and spatial arrangement. Further addition of hydrophilic SPES resulted in a membrane with reduced pore size and molecular weight cut-off as well as amplified negative charge and pure water permeance. During separation, the blend membranes exhibited higher rejection rates for nine types of small molecular weight (269.3–800 Da) dyes than for neutral polyethylene glycol molecules (200–1000 Da). This was attributed to the size effect and the synergistic effect between steric hindrance and charge repulsion. Notably, the synergistic impact decreased with dye molecular weight, while greater membrane negative charge enhanced small molecular dye rejection. Ideal operational stability and anti-fouling performance were best observed in M2 (PES/SPSf/SPES, 3.1 wt %). Summarily, this study demonstrates that SPES with –SO3 functional groups can be applied to control the microstructure and separation of membranes.

关键词: adipic acid     loose nanofiltration membrane     dye/salt selective separation     steric hindrance     charge effect    

标题 作者 时间 类型 操作

Multistage analysis method for detection of effective herb prescription from clinical data

null

期刊论文

遥感和精准农业技术在作物病害检测与管理中的应用实例

杨成海

期刊论文

通用、有效且轻量的PowerShell解混淆和语义敏感的攻击检测方法

熊春霖1,李振源1,陈焰2,朱添田3,王箭1,杨海4,阮伟5

期刊论文

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

null

期刊论文

Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

期刊论文

Z-scheme CdS/WO on a carbon cloth enabling effective hydrogen evolution

期刊论文

Determination of effective stress parameter of unsaturated soils: A Gaussian process regression approach

Pijush Samui, Jagan J

期刊论文

OPPORTUNITIES AND APPROACHES FOR MANIPULATING SOIL-PLANT MICROBIOMES FOR EFFECTIVE CROP NITROGEN USE

期刊论文

Facile fabrication of dolomite-doped biochar/bentonite for effective removal of phosphate from complex

期刊论文

Usability perceptions and beliefs about smart thermostats by chi-square test, signal detection theory, and fuzzy detection theory in regions of Mexico

Pedro PONCE, Therese PEFFER, Arturo MOLINA

期刊论文

Advances in airborne microorganisms detection using biosensors: A critical review

期刊论文

Recent advances in SERS detection of perchlorate

Jumin Hao, Xiaoguang Meng

期刊论文

UV-LED/P25-based photocatalysis for effective degradation of isothiazolone biocide

期刊论文

A fast antibiotic detection method for simplified pretreatment through spectra-based machine learning

期刊论文

and properties of PES/SPSf loose nanofiltration membranes using SPES as a hydrophilic polymer for the effective

期刊论文